A Comparison of the Boolean and Continuous Dynamics of Three-Gene Regulatory Networks

Timothy D. Comar
Department of Mathematics, Benedictine University, Lisle IL

Marihan Hegazy
Department of Mathematics, Benedictine University, Lisle IL

Miranda Henderson
Department of Mathematics, Benedictine University, Lisle IL

Daniel Hrozencik
Chicago State University, Chicago, IL

Abstract

We investigate the dynamics of three-gene regulatory networks with one feedback circuit using the Boolean and continuous models put forth by Gehrmann and Drossel [4]. We establish the existence of Hopf bifurcations in the continuous models and use these bifurcations to compare the models more closely. With this analysis we are able to establish the regions in the parameter space where the dynamical behavior of the models agree and where they disagree.

Keywords: Gene regulatory network ,Boolean dynamics ,Bifurcations

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