Ahmed AbdElkader Soliman Mahran
Department of Internal Medicine Faculty of Medicine, New Valley University, Egypt
Ahmed Mohamed Ghazy
Assistant Professor of Hepatology, Gastroenterology and Infectious Diseases Faculty of Medicine Al Azhar University, Egypt
Mostafa R. Bakry
Reproductive Medicine and IVF, Dar Al-Nokhba IVF Center, Cairo, Egypt
Ahmed Fakeih Sakr Elfors
Assistant Professor of Hepatology, Gastroenterology and Infectious Diseases Faculty of Medicine Al Azhar University, Egypt
Mohamed Gharib Mohamed
Assistant Professor of Hepatology, Gastroenterology and Infectious Diseases Faculty of Medicine Al Azhar University, Egypt
Osama Mostafa Abd Elrazik
Assistant Professor of Hepatology, Gastroenterology and Infectious Diseases Faculty of Medicine Al Azhar University, Egypt
Waleed Mohamed Mousa
Assistant Professor of Hepatology, Gastroenterology and Infectious Diseases Faculty of Medicine Al Azhar University, Egypt
Mohamed Mousa Hegazy
Assistant Professor of Hepatology, Gastroenterology and Infectious Diseases Faculty of Medicine Al Azhar University, Egypt
Mohamed Mahmoud Abdel-Halim
Assistant Professor of Hepatology, Gastroenterology and Infectious Diseases Faculty of Medicine Al Azhar University, Egypt
Mohamed Zakaria Abu-Amer
Assistant Professor of Hepatology, Gastroenterology and Infectious Diseases Faculty of Medicine Al Azhar University, Egypt
Ismail Ali Ismail Sakr
Lecture of Hepatology, Gastroenterology and Infectious diseases faculty of medicine Al Azhar University, Egypt
Mohamed Abdel Salam Abd El Fattah Badran
Lecture of Hepatology, Gastroenterology and Infectious diseases faculty of medicine Al Azhar University, Egypt
Mohamed Hamza El Sisi
Lecture of Hepatology, Gastroenterology and Infectious diseases faculty of medicine Al Azhar University, Egypt
Ayman Ahmed Shawky Said
Lecture of Hepatology, Gastroenterology and Infectious diseases faculty of medicine Al Azhar University, Egypt
Adel M. Abdou
Department of clinical pathology, Faculty of medicine, Al-Azhar University (boys), Egypt
Abdullah Mustafa Gaafar
Department of clinical pathology, Faculty of medicine, Al-Azhar University (boys), Egypt
Doaa Aly Abd El-Fatta
Department of clinical pathology, Faculty of medicine, Al-Azhar University (Girls), Egypt
Maha M. Elshafei
Associate Professor of Internal Medicine and Endocrinology Faculty of Medicine, Mansoura University, Egypt
Background: Metabolic dysfunction–associated steatotic liver disease (MASLD) is emerging as the leading chronic liver disease, closely linked with obesity, type 2 diabetes mellitus (T2DM), dyslipidemia, and hypertension. Beyond hepatic injury, MASLD is increasingly recognized as a systemic disorder associated with cardiovascular disease and chronic kidney disease (CKD). Microalbuminuria serves as an early biomarker of renal dysfunction and may reflect the systemic impact of MASLD. Objective: This study aimed to evaluate the prevalence and determinants of microalbuminuria among patients with MASLD and its associations with metabolic and renal parameters. Methods: A prospective cohort study was conducted including 60 MASLD patients, divided into two groups: Group 1 (MASLD with T2DM and/or hypertension) and Group 2 (MASLD without diabetes, hypertension, or cardiac disease). Clinical evaluation, anthropometric measures, laboratory tests, fatty liver index (FLI), and renal function markers including urinary albumin-to-creatinine ratio (ACR) and estimated glomerular filtration rate (eGFR) were assessed. Results: Group 1 patients exhibited higher BMI, waist circumference, fasting glucose, HbA1c, HOMA-IR, ALT, AST, GGT, triglycerides, LDL, and alpha-fetoprotein compared with Group 2. HDL was significantly lower. Renal assessment revealed a higher urinary ACR and lower eGFR in Group 1. The incidence of CKD was significantly greater in Group 1 (12 cases, 40%) versus Group 2 (2 cases, 6.7%), predominantly in stages I–II. Conclusions: Microalbuminuria is strongly associated with MASLD in patients with concurrent metabolic comorbidities. Early detection of albuminuria in MASLD patients may identify those at increased risk of CKD, emphasizing the need for integrated hepatic–renal risk assessment in clinical practice.
